Spermidine/spermine n1-acetyltransferase 1 (sat1)—a potential gene target for selective sensitization of glioblastoma cells using an ionizable lipid nanoparticle to deliver sirna

HIGHLIGHTS

  • who: Vinith Yathindranath and colleagues from the Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB R E , Canada have published the article: Spermidine/Spermine N1-Acetyltransferase 1 (SAT1)u2014A Potential Gene Target for Selective Sensitization of Glioblastoma Cells Using an Ionizable Lipid Nanoparticle to Deliver siRNA, in the Journal: Cancers 2022, x of 31/01/2022
  • what: The authors examined the impact of SAT1 KD on GB survival under both normal conditions and following exposure to radiation and various chemotherapeutics. The authors focused on DODAP, DSPC, desired physicochemical and drug loading/delivery properties . . .

     

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