HIGHLIGHTS
- who: Advance access, publication and October, from the State Key Laboratory100101, China Tsinghua University have published the research work: Protein & Cell, in the Journal: (JOURNAL)
SUMMARY
Super-active mitochondrial respiration in mESCs generates the majority of cellular ATP. (D) RNA-seq meta-analysis reveals that OXPHOS inhibition results in dramatic changes of gene_expression at the whole-transcriptome level. Heatmaps show relative expression levels of genes involved in pluripotency, TCA pathway, amino_acid biosynthesis, fatty_acid metabolism, pentose_phosphate_pathway, and glycolysis/gluconeogenesis upon OXPHOS or glycolysis inhibition. Considering that OXPHOS inhibition reprograms metabolic gene_expression, the authors asked . . .
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