HIGHLIGHTS
SUMMARY
The lineage-directed strategy has been found to have an important part in mediating the benzene toxicity effects on adult stem_cells, specifically in the HSC and multilineage hematopoietic stem and progenitor cell (HSPCs) niche. Previous studies have reported some evidence of benzene toxicity affecting HSPCs` selfrenewal and differentiation pathways that led to the clonal expansion of leukemic stem_cells (LSCs). In adult hematopoiesis studies, reports suggest that the presence of an intrinsic self-protecting machinery in HSPCs in adults can protect the stem_cell compartment in the hematopoietic system. "Placenta-mediated Toxicity" discusses how trophoblast barriers . . .
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