Dna-binding mechanism and evolution of replication protein a

HIGHLIGHTS

• who: Clu00e9ment Madru from the (UNIVERSITY) have published the paper: DNA-binding mechanism and evolution of replication protein A, in the Journal: (JOURNAL) of 14/03/2023
• what: The authors report three crystal_structures and five cryo-EM structures of Pyrococcus abyssi RPA (hereafter referred to PabRPA), in its apo form as well as bound to ssDNA. Based on structural and biochemical evidence, including site-directed_mutagenesis, the authors propose that the acidic AROD domain inhibits DNA binding when it contacts OB-1.
• how: The DNA-binding properties of each subunit of PabRPA were tested . . .
  

   

  

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