Codon-optimized tdp-43 mediates neurodegeneration in a drosophila model of als/ftld

HIGHLIGHTS

• who: . and colleagues from the United States AandM University Kingsville have published the article: Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD, in the Journal: (JOURNAL)
• what: In contrast to previous fly models, the authors demonstrate that the CO-TDP-43 lines lead to increased TDP-43 expression, hyperphosphorylation, and form toxic cytoplasmic aggregates that gives rise to strong phenotypes when expressed in the fly retina, wing, and notum. The authors report a novel transgenic D. melanogaster resource to better understand TDP-43 mediated neurodegeneration.
• how: Taken together . . .
  

   

  

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