Regioselective synthesis and molecular docking studies of 1,5-disubstituted 1,2,3-triazole derivatives of pyrimidine nucleobases

HIGHLIGHTS

• who: Vincenzo Algieri and collaborators from the Department of Chemistry and Chemical Technologies, University of Calabria, Rende, Italy have published the research: Regioselective Synthesis and Molecular Docking Studies of 1,5-Disubstituted 1,2,3-Triazole Derivatives of Pyrimidine Nucleobases, in the Journal: Molecules 2022, 27, x FOR PEER REVIEW of /2022/

SUMMARY

Use of N1-propargyl dine nucleobases allows the introduction of a methylene bridge at C-5 of the triazole, which pyrimidine nucleobases allows the introduction of a methylene bridge at C-5 of the triacould mimic the behavior of "fleximers . . .

 



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