HIGHLIGHTS
- who: Gurvir S. Virdi from the (UNIVERSITY) have published the research: Protein aggregation and calcium dysregulation are hallmarks of familial Parkinsonu2019s disease in midbrain dopaminergic neurons, in the Journal: (JOURNAL) of 16/03/2022
- what: The authors established a modified approach to obtain highly enriched mDA neurons and the authors demonstrate their capacity to faithfully model key aspects of PD pathogenesis with temporal resolution. The analysis demonstrates that, at 48 days of differentiation, the method predominantly generates cells of mDA neuronal identity, with a clear developmental trajectory defined for the remaining NPCs to differentiate into . . .
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