Dehp mediates drug resistance by metabolic reprogramming in colorectal cancer cells

HIGHLIGHTS

  • who: Yue Wu from the Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People`s Hospital (Affiliated People`s Hospital, Hangzhou Medical College), Zhejiang Province, Hangzhou, China have published the article: DEHP mediates drug resistance by metabolic reprogramming in colorectal cancer cells, in the Journal: (JOURNAL)
  • what: The authors showed that DEHP could trigger the metabolic reprogramming of colorectal cancer cells promote cell growth and decrease fluorouracil (5-FU) sensitivity.
  • how: These data indicated that DEHP administration leads to a significantly decreased in both glycolysis and glycolysis capacity.
 

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