HIGHLIGHTS
- who: Aviram Kogot-Levin et al. from the Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Miami, Miami, Florida, USA have published the research: Mapping the metabolic reprogramming induced by sodium-glucose cotransporter inhibition Diabetes Unit and Endocrine Service Hadassah-Hebrew University, in the Journal: (JOURNAL)
SUMMARY
The kidney has an important role in regulating glucose homeostasis in mammals. Approximately 180 g/ day glucose is filtered in the glomeruli, the vast majority being reabsorbed in kidney proximal tubule cells (KPTCs), mainly (90%) through sodium-glucose cotransporter 2 (SGLT2). Strikingly, large-scale trials consistently . . .
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