Ef cient and error-free correction of sickle mutation in human erythroid cells using prime editor-2

HIGHLIGHTS

• who: December et al. from the University College Cork, Ireland United States have published the paper: Ef cient and error-free correction of sickle mutation in human erythroid cells using prime editor-2, in the Journal: (JOURNAL)
• what: The authors describe the use of prime editing for the correction of HbS mutation in human erythroid cell line (HUDEP2) and demonstrate the reconstitution of functional adult haemoglobin in the SCA model with high efficiency and precision. Prior to evaluating prime editing in erythroid cell lines for correction of SCA mutation, the authors aimed at developing a . . .
  

   

  

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