Plasma rich in growth factors (prgf) and leukocyte-platelet rich fibrin (l-prf): comparative release of growth factors and biological effect on osteoblasts

HIGHLIGHTS

SUMMARY

Autologous platelet concentrates (APCs) are used as surgical adjuvants to improve wound healing and tissue regeneration. There are many preparation protocols which result in different end products, but the underlying biological mechanism is common to all APCs and involves the release of several growth factors (GFs) and cytokines from the cells-platelets and sometimes leucocytes, depending on the APC-included on a fibrin matrix. More specifically, previous studies have suggested that the L-PRF fibrin matrix allows a slow and progressive release of GFs over 7 days, whereas the P-PRP fibrin scaffold seems . . .

 



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