Molecular characterization of richter syndrome identifies de novo diffuse large b-cell lymphomas with poor prognosis

HIGHLIGHTS

  • who: Julien Brosu00e9us from the (UNIVERSITY) have published the research: Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis, in the Journal: (JOURNAL)
  • what: The authors characterize 58 primary human RS samples by genomewide DNA methylation and whole-transcriptome profiling. The authors perform genome-wide DNAm analysis and wholetranscriptome profiling for a large series of primary human RS samples, and comprehensively compare the findings to those in CLL and DLBCL. As nearly all de novo DLBCLs harbor a mutated IGHV, the authors propose that RS clonally related to . . .

     

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