HIGHLIGHTS
- who: Qian Liu from the Xiamen University, China have published the research work: Mesophilic Argonaute-based isothermal detection of SARS-CoV-2, in the Journal: (JOURNAL)
- what: The authors aimed to establish an isothermal assay based on the stepwise cleavage activity of mesophilic Ago. The authors propose a further combination with isothermal amplification methods, such as reverse transcription-recombinase aided amplification (RT-RAA), that would efficiently detect targets at a lower concentration.
- how: To address the shortcomings of CRISPR and thermophilic Agos the authors designed a one-step mesophilic Ago-based isothermal detection . . .
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