Ssris differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids

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• who: Yukitoshi Izumi from the Hippocampal slice preparation Protocols for animal experiments were approved by the Washington University IACUCHippocampal slices were prepared from randomly selected postnatal day (P), Harlan Sprague-Dawley male albino rats (Indianapolis IN) using published methods [33, ]. For slice preparation, rats were anesthetized with isoflurane, and dissected hippocampi were pinned on an agar base in artificial cerebrospinal fluid (ACSF) containing (in mM): , NaCl, KCl, MgSO4, CaCl2,NaH PO4, NaHCO3, glucose, gassed with, %, % , at, oC. The dorsal two-thirds of the hippocampus was cut into , u00b5m slices using a rotary slicer and maintained in ACSF . . .
  

   

  

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