Thiophosphate analogs of coenzyme a and its precursors—synthesis, stability, and biomimetic potential

HIGHLIGHTS

• who: Christian Lu00f6cherer and colleagues from the Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld , have published the research work: Thiophosphate Analogs of Coenzyme A and Its Precursorsu2014Synthesis, Stability, and Biomimetic Potential, in the Journal: Biomolecules 2022, 12, 1065. of /2022/
• how: Since compound C3b had an increased stability against Nudt7 degradation the authors investigated whether its biosynthetic precursor C1 the thiophosphate analog of PPanSH still exhibits comparable properties in terms of biocompatibility and alleviation of CoA deficiency in a cell culture model.
• future: Future studies should address the intracellular . . .
  

   

  

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