Idol depletion protects against spontaneous atherosclerosis in a hamster model of familial hypercholesterolemia

HIGHLIGHTS

  • who: Chenxi Liang and colleagues from the Laboratory of Lipid Metabolism, Institute of MedicineHebei University, Shijiazhuang, Hebei, China have published the Article: Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia, in the Journal: Oxidative Medicine and Cellular Longevity of 24/05/2022
  • what: In this study an Idol knockout (Idol-/-) hamster model was developed using CRISPR/Cas9 gene editing system to investigate the effect of Idol depletion on plasma lipid metabolism and atherosclerosis.
  • how: The results showed that there were no significant differences in hepatic LDLR protein and . . .

     

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