Abt-333 (dasabuvir) increases action potential duration and provokes early afterdepolarizations in canine left ventricular cells via inhibition of ikr

HIGHLIGHTS

• who: Zsigmond Mu00e1tu00e9 Kovu00e1cs and colleagues from the Department of Physiology, Faculty of Medicine, University of, have published the article: ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of IKr, in the Journal: Pharmaceuticals 2023, 488 of 20/05/2018
• what: This AP prolongaCYP2C8 . tionAs was not statistically (p=0.08) forgroup the duration ofisthe AP of from peak to ABT-333 contains asignificant methanesulfonamide and there a risk QTthe prolonga50% repolarization (APD 50), but the prolongation tendency was reversible upon washout, tion, the authors . . .
  

   

  

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