HIGHLIGHTS
SUMMARY
Extramedullary relapse most commonly involves the central nervous system but may also present as a testicular isolated or concomitant relapse in males. Information about testicular leukemia is difficult to analyze, considering difficulties to compare patients treated with protocols that are not in use contemporaneously to children treated nowadays, the different results of leukemia treatment in developed and low/medium income countries (LMIC) results referring to multiple age groups, the relative rarity of the disease and the limited quality of the literature. Lower prevalence of testicular ALL is strongly dependent on modern chemotherapy protocols: testicular . . .
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