The acute antiallodynic effect of tolperisone in rat neuropathic pain and evaluation of its mechanism of action

HIGHLIGHTS

  • who: Pu00e9ter P. Lakatos and collaborators from the Department of Pharmacodynamics, Semmelweis University, Nagyvu00e1rad tu00e9r have published the research: The Acute Antiallodynic Effect of Tolperisone in Rat Neuropathic Pain and Evaluation of Its Mechanism of Action, in the Journal: (JOURNAL) of 24/08/2022
  • what: This work was carried out to examine whether tolperisone could reduce neuropathic pain in rats induced by partial sciatic nerve ligation (pSNL) and modulate spinal cord glutamatergic systems.
  • how: The present results showed that CSF glutamate level was significantly increased in rats with neuropathy and this elevated concentration . . .

     

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