Transcriptome analysis of sputum cells reveals two distinct molecular phenotypes of “asthma and chronic obstructive pulmonary disease overlap” in the elderly

HIGHLIGHTS

• who: Suh-Young Lee from the Participants aged , years or older were recruited from the Seoul National University Hospital (Seoul, Korea)Asthma was diagnosed according to the Global Initiative for Asthma guideline (GINA) on the basis of current (past , months) episodic respiratory symptoms and demonstrated evidence of airway hyperresponsiveness to methacholine or positive bronchodilator response [10]. The diagnosis of COPD was based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline [11]. A history of exposure to risk factors, such as tobacco smoking, exposure to environmental tobacco smoke, biomass fuel or occupational exposure to dust . . .
  

   

  

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