Cholesterol-induced lrp3 downregulation promotes cartilage degeneration in osteoarthritis by targeting syndecan-4

HIGHLIGHTS

• who: Chenxi Cao from the High cholesterol aggravates OA cartilage degeneration Initially, we collected clinical data of , OA patients undergoing total knee replacement (TKA) in Peking University Third Hospital and , non-OA patients (meniscal injury as control), including blood total cholesterol (TC), LDL, and body mass index (BMI) (Supplementary Table, )We found that compared with non-OA patients, TC and LDL were significantly higher in OA patients, accompanied by larger BMI and more metabolic diseases, which indicated that there may be a link between hyperlipidemia and the development of OA (Fig., a). Subsequently, we investigated the impact . . .
  

   

  

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