Hemispheric lateralization of semantic processing before and after aripiprazole treatment in first-episode psychosis or ultra-high risk state

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SUMMARY

    Many anatomical studies using post-mortem autopsy, brain CT, or brain MRI have revealed decreased asymmetry, and, thus lower indices of language lateralization in patients with schizophrenia4-6. A few fMRI studies have examined abnormalities of language pathways in patients with schizophrenia, and the most consistent finding has been disturbance of left hemispheric dominance, irrespective of language task13. More specifically, some studies have reported reduced language-related lateralization in first-episode patients regardless of whether the patients were treatment-naïve or undergoing initial antipsychotic treatment20,21. No prior study has investigated whether disturbed . . .

     

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