Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease

HIGHLIGHTS

• who: Houfu Leng from the Mouse models Animal experiments were undertaken under UK Home Office Project Licenses, and, in accordance with the UK Animal (Scientific Procedures) Act The UK Home Office approved the experiments on animals performed for this study. Customed eliglustat diet was formulated into either a standard rodent diet or a, % high fat diet, both at, .075% w/w (, mg/kg/day for all in vivo experiments) by TestDiet29. Sex and age matched C BL/ J mice and CD45.1+mice were purchased from Charles River, UK. C BL/KaLwRijHsd mice were purchased from Harlan . . .
  

   

  

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