Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice

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• who: Vincent Pascoli from the Animals Mice (age, weeks) were heterozygous BAC-transgenic mice expressing tomato under D R control (Drd1a-td-tomato)To identify D, SPNs, Adora2a-cre was used (Jackson Laboratories). Weight and sex were distributed homogeneously among the groups. All transgenic mice were backcrossed into C BL/, for four or more generations. All animals were kept in a temperature- and humidity-controled environment with an inverted, h-light/12h-dark cycle (lights on at, :, pm). All procedures were approved by the Institutional Animal Care and Use Committee of the University of Geneva and by . . .
  

   

  

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