HIGHLIGHTS
SUMMARY
The compound substituted with the naphthalene ring showed MAO-B-selective inhibitory activity (IC50 value of 0.38 µM vs. IC50 of 2.20 µM for MAO-A, MAO-B selectivity index of 5.8), while the compound substituted with pyridyl showed slightly poorer MAO inhibitory activities (IC50 values of 21.3 and 11.9 µM for MAO-A and MAO-B, respectively). A structure-based computational study was conducted on all the synthesized compounds to understand how they fit within the MAO-A and MAO-B active_sites. To elicit the MAO-A and . . .
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