HIGHLIGHTS
SUMMARY
Triglyceride (TG) were selected as instrumental variables. The causal effect of blood lipid profile, particularly low-density lipoprotein cholesterol (LDL-C), on the risk of developing OA remains unclear. To date, the effects of statins on OA have aroused great interest from researchers; however, results are conflicting and vary from reduced risk to no effect or even an increased risk of OA. The authors aimed to use a Mendelian randomization (MR) approach to investigate the effect of blood lipid profiles and lipid-lowering agents on OA risk. In a prospective cohort study of 5 . . .
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