Cell type-specific interpretation of noncoding variants using deep learning-based methods

HIGHLIGHTS

• who: GigaScience and colleagues from the AIRI, Moscow, Russia have published the research work: Cell type-specific interpretation of noncoding variants using deep learning-based methods, in the Journal: (JOURNAL) of December/11,/2022
• what: The authors show here that available epigenetic characteristics of human cell types are extremely sparse limiting those approaches that rely on specific epigenetic input. The authors propose a new neural network architecture DeepCT which can learn complex interconnections of epigenetic features and infer unmeasured data from any available input. The authors show that DeepCT can learn cell type-specific properties . . .
  

   

  

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