Spop inhibits braf-dependent tumorigenesis through promoting non-degradative ubiquitination of braf

HIGHLIGHTS

• who: Kai Feng from the Laboratory of Genetic Engineering, MOE Engineering Research Center China University Shanghai Cancer Center, Fudan University, Shanghai , have published the paper: SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF, in the Journal: (JOURNAL)
• what: The authors focused on three hotspot mutants (E47K, S80R, and W131G). The authors showed that the CRL3-SPOP complex mediates the non-degradative ubiquitination of BRAF, which reduces the interaction between BRAF and other MAPK/ERK pathway components, resulting in subsequent MAPK/ERK inactivation (Fig 8).
• how: Given that BRAF is . . .
  

   

  

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