Analysis of chromatin data supports a role for cd14+ monocytes/macrophages in mediating genetic risk for juvenile idiopathic arthritis

HIGHLIGHTS

• who: Elizabeth A. Crinzi from the The University of Manchester, United Kingdom have published the paper: Analysis of chromatin data supports a role for CD14+ monocytes/macrophages in mediating genetic risk for juvenile idiopathic arthritis, in the Journal: (JOURNAL)
• what: The authors provide additional evidence that JIA risk variants impact innate immunity. The authors investigated the chromatin architecture surrounding 36 JIA risk loci in CD14+ monocytes. The authors provide evidence, based on the chromatin architecture surrounding the genetic risk haplotypes, that genetic risk for JIA exerts effects in cells of the monocytemacrophage lineage.
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