HIGHLIGHTS
SUMMARY
More recently, the authors have further developed novel nanoemulsions of IMQ with superior pharmaceutical and immunization properties, inducing even more potent specific CD8+ as well as CD4+ T_cell responses16,17. In detail, IMQ-TCI requires depilation potentially causing skin irritation and application on the complete dorsum of mice to induce virus- or tumor-protective T_cell responses being a disproportional skin area when considering translation into humans. When applied prior to IMQ-TCI, dithranol strongly amplified specific T_cell responses compared to IMQ-TCI alone, while dithranol alone had no adjuvant effect on systemic immune_responses. Beyond . . .
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