HIGHLIGHTS
SUMMARY
Over the last decades, a huge number of macromolecules, including natural polymers, were considered as constituents for drug-delivery systems (DDS) in different formulations: microspheres, microparticles, nanoparticles (NPs), nanodroplets, liposomes, micelles and nanomicelles, hydrogels, films, nanowires, bio-conjugates, medical adhesives and others. Commercially, DEX is usually obtained from L mesenteroides or L dextranicum fermentation in a media with sucrose and a considerable nitrogen source. In the first mechanism, the monomers are sequentially added at the non-reducing_end of a growing chain using a high-energy donor. The second mechanism consists of the sequential addition . . .
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