HIGHLIGHTS
- who: LUBAC and collaborators from the Chapman University, United States have published the Article: Structural basis for ubiquitylation by HOIL-1, in the Journal: (JOURNAL)
- future: Future studies need to provide an understanding how HOIL-1 is able to ubiquitylate carbohydrates in molecular detail. histidine to assist catalysis as observed for other RBR ligases.
SUMMARY
Stimulation of innate and adaptive immune receptors trigger the activation of multiple ubiquitin ligases which orchestrate the initiation of inflammatory gene_expression by transcription factor NF-κB (Haas et_al, 2009). LUBAC is a heterotrimeric ligase which consists . . .
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