Circprkch modulates extracellular matrix formation and metabolism by regulating the mir-145/hgf axis in osteoarthritis

HIGHLIGHTS

• who: Wenzhong Que from the Cartilage samples were obtained from , OA patients (, men and , women, age range, years) who underwent total knee replacement at the Affiliated Nanping First Hospital of Fujian Medical UniversityNormal articular cartilage samples were isolated from , donors (, men and , women, age range, years), who underwent trauma without a history of OA or rheumatoid arthritis. All cartilage samples were immediately frozen and stored in liquid nitrogen. The diagnosis of OA patients was made according to the criteria of the American College of Rheumatology. OA severity was graded using weight-bearing anteroposterior radiographs of the affected . . .
  

   

  

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