Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia

HIGHLIGHTS

• who: Beata Jablonska from the National Institutes of Health guidelinesTo obtain mice in which Sirt, or Sirt, was conditionally ablated in OPCs, we crossed Sirt1fl/fl or Sirt2fl/fl mice (where loxP sites flanked exon , of the Sirt, gene, or exons, of the Sirt, gene) with PDGFRu03b1CreERT transgenic mice, which express the tamoxifen-inducible form of Cre in OPCs expressing PDGFRu03b1. To obtain mice in which Sirt, was conditionally overexpressed in PDGFRu03b1+ OPCs or PLP+ mature OLs, we crossed Sirt STOP mice with PDGFRu03b1 CreERT or PLPCreERT transgenic mice, respectively. Both male and female mice were analyzed . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.