HIGHLIGHTS
SUMMARY
One potential immune mechanism in autoimmune-mediated secondary psychiatric disorders that are associated with autoantibodies to intracellular antigens, is likely to be characterized predominantly by a T_cell-dependent mechanism. This suggestion is based on the observation that in encephalitides associated with antibodies and intracellular antigens, CD8+ T_cells were frequently found in encephalitic brain tissue. In the view, in addition to autoimmunity in psychiatric disorders (which may be evidenced by autoantibodies on the one hand, but may also be due to T_cell-driven immune_responses on the other), many other factors that may contribute to autoimmunity . . .
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