HIGHLIGHTS
- who: Roshan Paudel et al. from the School of Systems Biology, George Mason University, Fairfax, VA, USA have published the paper: Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2G112+5X Mutation in a Guinea Pig Ventricular Myocyte Computational Model, in the Journal: Genes 2023, 23 of 13/Oct/2022
- what: This study demonstrated that alternans is the mechanisms responsible for generating arrhythmia during u03b2-adrenergic stimulation in the mutant myocyte. This paper examines(u03a6 them )impact of was the mutation Catwo dynamics in intracellular Ca regulation coefficient, of RyR2 increasedon and morphological . . .
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