HIGHLIGHTS
SUMMARY
Advanced tissueengineered scaffolds provide a platform to achieve such a therapy by their ability to mediate multiple reparative processes, such as, (i) stem_cell incorporation and protection to improve transplantation survival, (ii) chemical enhancement of growth and modulation of inhibitory pathological processes and_(iii) provision of the physicochemical environment needed for regenerating tissue (e_g, alignment and extracellular matrix cues). The potential to engineer pre-aligned, stem_cell implants has also been demonstrated. Seeding of astrocytes and oligodendrocyte precursor cells (OPCs) on aligned fibres resulted in alignment and elongation of both cell types along the fibres. The . . .
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