Genetic analyses of the electrocardiographic qt interval and its components identify additional loci and pathways

HIGHLIGHTS

SUMMARY

    There were no GWS findings for QRS or female X-chromosome analyses, and no suggestive evidence of association on a lookup of the lead QT/JT variant (rs55891214) in these analyses (P > 0.05). rs55891214 is highly correlated (r2 > 0.9) with lead variants reported in GWAS for serum testosterone, estradiol levels, male-pattern baldness, and heel bone mineral density19-22. Nature Communications | 13:5144 Overlap of genetic contributions and heritability of QT, JT, and QRS There was substantial overlap of multi-ancestry JT and QT GWAS loci (130/200, 65%) but less between . . .

     

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