HIGHLIGHTS
SUMMARY
In 2017, the WHO classification introduced lineage-based classification of pituitary tumours, as determined by transcription factor and hormonal immunohistochemistry (IHC). Pituitary stem_cells undergo lineage commitment into mature hormone-producing cell types (ACTH, LH, FSH, TSH, GH, PRL) following downregulation of stem_cell markers and upregulation of differentiation-specific transcription factors. Steroidogenic factor 1 (SF1) gives rise to gonadotroph cells; T-box transcription factor 19 (TPIT) gives rise to corticotroph cells and pituitary-specific positive transcription factor (PIT1) gives rise to lactotroph, somatotroph and thyrotroph cells (Fig 1). Adoption of transcription factor analysis has been . . .
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