HIGHLIGHTS
SUMMARY
Neural stem_cells (NSCs) and mesenchymal stem_cells (MSCs) have received a great amount of attention in TBI therapy, avoiding the ethical issues surrounding the use of human embryonic stem_cells and the controversial issues around induced pluripotent stem_cells. Isolation and culture of mesenchymal stem_cells Primary bone mesenchymal stem_cells (BMSCs) were isolated from murine compact bone and cultureexpanded as described in the previous report. Frontal bone mesenchymal stem_cells (FbMSCs) and parietal bone mesenchymal stem_cells (PbMSCs) were prepared from frontal or parietal bone of newborn C57BL/6 N, respectively. In Matrigel-treated TBI group and FbMSC-treated TBI . . .
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