HIGHLIGHTS
- who: Changnan Wang from the (UNIVERSITY) have published the paper: A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience, in the Journal: (JOURNAL) of 11/06/2022
- what: The authors report an exceptionally large and evolutionarily conserved protein LPD-3 in C. elegans that mediates lipid trafficking to confer cold resilience. The authors show that LPD-3 is critical for fat-7 expression, normal distribution of phospholipids at the PM, and organismic resilience to severe cold stress. Based on the integrated genetic, protein structural, cell biological and organismic phenotypic analyses, the . . .
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