Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer

HIGHLIGHTS

• who: Katie Cockburn from the Divisions (%) have published the research work: Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer, in the Journal: (JOURNAL) of 23/09/2022
• what: The authors show that differentiation, from commitment to exit from the stem_cell layer, is a multi-day process wherein cells transit through a continuum of transcriptional changes with upregulation of differentiation genes preceding downregulation of typical stemness genes. To understand this journey in more detail, in this Letter, the authors focused on the long-standing observation that a subset of . . .
  

   

  

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