Zebrafish mutants reveal unexpected role of lrp5 in osteoclast regulation

HIGHLIGHTS

  • who: Iryna Khrystoforova from the University of Bristol, United Kingdom have published the paper: Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation, in the Journal: (JOURNAL)
  • what: In contrast, the previously reported zebrafish mutants carry the mutation in exon 5 that creates a stop codon at amino_acid position 284, meanwhile zebrafish mutants the authors report here carry the mutation in exon 2 with stop codon at 54 aa. The authors show that pathways responsible for osteoclastogenesis are differentially expressed in lrp5 mutants Frontiers in Endocrinology frontiersin.org 10.3389/fendo.2022.985304 discern . . .

     

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