Non-transport roles of nuclear import receptors: in need of the right balance

HIGHLIGHTS

• who: November and colleagues from the University of Wyoming, United States have published the Article: Non-transport roles of nuclear import receptors: In need of the right balance, in the Journal: (JOURNAL)
• what: The authors focus on NIR cargoes found to be mutated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and summarise how NIRs mitigate the pathogenetic effects of these mutations.

SUMMARY

In proteomics studies, importin beta members have diversified partners and cargo preferences in different cell types, cell cycle phases and subcellular compartments (Roscioli et_al, 2012; Kimura et_al . . .

 



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