Polymeric immunoglobulin receptor suppresses colorectal cancer through the akt-foxo3/4 axis by downregulating lamb3 expression

HIGHLIGHTS

• who: Ding Zhang from the University Hospital of Parma, Italy have published the paper: Polymeric immunoglobulin receptor suppresses colorectal cancer through the AKT-FOXO3/4 axis by downregulating LAMB3 expression, in the Journal: (JOURNAL)
• what: The authors wanted to investigate whether PIGR affect these pathways by downregulating LAMB3. The study showed that the differences between CRC and adjacent normal tissues in methylation, mRNA and protein expression were significant and that PIGR methylation and expression varied with the tumor stage.
• how: These results showed that PIGR expression was reduced in CRC tissues . The overall . . .
  

   

  

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