Crhr1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia

HIGHLIGHTS

  • who: Tong Ying Wang from the East Carolina University, United States have published the article: CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia, in the Journal: (JOURNAL)
  • what: Transcriptional factors, HIFs can bind to a specific binding_site, hypoxia response element (HRE) in the promoter of the target gene , therefore, the authors propose that the HIFs are candidates for pioneer or non-pioneer factors that might be involved in the regulation of transcription during pituitary development and homeostasis during physiological and psychological stress . This study provides insights into understanding the mechanisms . . .

     

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