Thalidomide attenuates mast cell activation by upregulating shp-1 signaling and interfering with the action of crbn

HIGHLIGHTS

  • who: Hyeun-Wook Chang et al. from the College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea have published the Article: Thalidomide Attenuates Mast Cell Activation by Upregulating SHP-1 Signaling and Interfering with the Action of CRBN, in the Journal: Cells 2023, 469 of 11/Nov/2021
  • what: The authors aimed to evaluate the anti-allergic activity of thalidomide and the underlying mechanism using mouse bone marrow-derived mast cells (BMMCs) and passive cutaneous anaphylaxis (PCA) mouse models. The authors showed that thaapeutic effects mast cell-mediated diseases. The authors showed lidomide inhibits Fcu03b5RI . . .

     

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