HIGHLIGHTS
SUMMARY
Conventional T_cells provide lifelong protection against infection and cancer by recognizing their cognate antigens and mediating effector functions. To ensure that the host can exert various immune_responses in a context-specific manner, T_cells have extensive diversity in their sub-lineages. T_cells possess proliferative potential and generate self-renewing long-lived populations, which are features shared with the multipotent hematopoietic progenitor cells and stem_cells, respectively. The authors propose that this distinctive positioning as T_cells can be supported by combinatorial actions of transcription factors, instead of relying on a lineage-specific "master regulator". After T-lineage . . .
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