Cerebrospinal fluid proteomic study of two bipolar disorder cohorts

HIGHLIGHTS

• who: Anniella Isgren from the differed between patients and controlsIn the present study, we survey a broader set of CSF proteins by using three Olink Multiplex panels, whereof one specifically targets immune markers. Although pro-inflammatory immune dysregulation and microglia activation have been implicated in bipolar disorder [8-11], findings are conflicting and the role of immune dysfunction in bipolar disorder is as yet undecided [6, , ]. Our primary aim was to test if CSF protein concentrations differ between patients with bipolar disorder and controls in two independent cohorts. The secondary aim was to investigate if case-control . . .
  

   

  

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