HIGHLIGHTS
- who: Jinqiu Fu from the A total of , patients (all the patients treated with the same protocol from January , to May, ) were enrolled and treated using the CCCG-, protocol (a modification of the CCCG-, protocol) [16] at Shandong University Qilu Hospital, ChinaThe study was approved by the Ethics Committee of Shandong University Qilu Hospital. Written informed consent was obtained from each participant`s parent or legal guardian, prior to enrollment and treatment. Fifty-four fasting blood samples were obtained before HDMTX therapy (day, used as the control samples) and after HDMTX therapy (day, ). Metabolite levels reflect the . . .
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